تاثیر پرفیوژن منقطع در بای پس قلبی ریوی روی مارکرهای بیوشیمیایی و فعالیت کلیه در بیماران تحت جراحی قلب

محمدزاده, علیرضا and جعفری, ناصر and حسن پور, محمد and سهندی فر, سهیل and غفاری, مسعود and علائی, واحد (1392) تاثیر پرفیوژن منقطع در بای پس قلبی ریوی روی مارکرهای بیوشیمیایی و فعالیت کلیه در بیماران تحت جراحی قلب. American Journal of Cardiovascular Disease ــ 3 (3). pp. 158-162. شاپا 2160-200X

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Effects of pulsatile perfusion during cardiopulmonary bypass on biochemical markers and kidney function in patients undergoing cardiac surgeries

English Abstract

Abstract: For several years there is no conclusive guideline on the effectiveness of pulsatile or non-pulsatile perfusion during cardiopulmonary bypass (CPB) in patients undergoing cardiac surgeries. In this study, we evaluated the effect of pulsatile versus continuous perfusion on the myocardial release of the cardiac biochemical markers including, creatine phosphokinase (CPK), cardiac creatine kinase (CK-MB), and lactate dehydrogenase (LDH), and also kidney function tests including: blood urea nitrogen test (BUN) and creatinine test (Cr) in patients that underwent both pulsatile and non-pulsatile methods before and after heart surgeries. A total of 80 patients were enrolled in this study, 40 patients in each pulsatile and non-pulsatile group. Venous blood samples were drown from each patient in two groups before operation and after operation at, 24, 48, and 72 h and analyzed separately for CPK, its cardiac isoenzyme (CK-MB), LDH, BUN and Cr. There were no significant differences between the two groups with regard to preoperative parameters such as sex, age, and body surface area. Our study shows that the effect of pulsatile perfusion on cardiac and kidney function is better than the non-pulsatile method.

Item Type:Article
زبان سند : انگلیسی
نویسنده مسئول :علیرضا محمدزاده
نویسنده :ناصر جعفری
نویسنده :محمد حسن پور
نویسنده :سهیل سهندی فر
نویسنده :مسعود غفاری
نویسنده :واحد علائی
Additional Information:Indexing: PubMed/PMC , Google Scholar
کلیدواژه ها (انگلیسی):Cardiopulmonary bypass , pulsatile , non-pulsatile , biochemical markers , kidney function
Subjects:QU Biochemistry
WG Cardiovascular System
WJ Urogenital System
WO Surgery
Divisions:Faculty of Medicine > Department of Surgery
Faculty of Medicine > Department of Basic Sciences > Department of Biochemistry
ID Code:4577
Deposited By: Dr Alireza Mohammadzadeh
Deposited On:07 Jun 1392 08:29
Last Modified:16 Nov 1399 08:51

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