کیهان منش, رعنا ، علیپور, محمد رضا ، ابراهیمی, هادی ، اصلانی, محمدرضا (1397) اثرات چاقی ناشی از رژیم غذایی بر روی پاسخ دهی تراشه به متاکولین، سطوح ویسفاتین تراشه، و تغییرات هیستولوژیک ریه در رتهای ویستار ماده حساس شده با اوآلبومین. Inflammation ــ 41 (3). ص.ص.846-858. شاپا 0360-3997
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آدرس اینترنتی رسمی : https://link.springer.com/article/10.1007/s10753-0...
عنوان انگليسی
Effects of Diet-Induced Obesity on Tracheal Responsiveness to Methacholine, Tracheal Visfatin Level, and Lung Histological Changes in Ovalbumin-Sensitized Female Wistar Rats
خلاصه انگلیسی
Many studies have shown a close relationship between obesity and asthma severity. In the present study, the effects of diet-induced obesity were examined on airway responsiveness to methacholine in addition to visfatin level in female Wistar rats’ tracheae after sensitization with ovalbumin. The rats were divided into four groups: control with normal diet (ND), ovalbumin (OVA)-sensitized with normal diet (S + ND), high-fat diet (HFD), and OVA-sensitized with a high-fat diet (S + HFD). The animals were fed for 8 weeks with standard pelts or high-fat diet and then sensitized and challenged with OVA or saline for another 4 weeks. At the end of the study, the tracheae were isolated and assessed for airway responsiveness and visfatin protein levels. Diet-induced obesity groups developed increased weight and obesity indices (p < 0.001). After sensitization with OVA and diet-induced obesity, there were marked leftward shifts in methacholine concentration-response curves in S + HFD group compared to other groups. Also, maximum response was the highest (p < 0.05 to p < 0.001), EC50 was the lowest (p < 0.05 to p < 0.001), and visfatin protein level was the highest (p < 0.05 to p < 0.01) in S + HFD. According to results, diet-induced obesity caused airway hyperresponsiveness to methacholine and enhanced visfatin protein levels in the tracheae of ovalbumin-sensitized female rats. Our results suggested that, in obese ovalbumin-sensitized conditions in female rats, the local production of adipocytokines, such as visfatin, may be increased, resulting in the deterioration of inflammation in lungs. This finding shows a possible mechanism for the altered phenotype in obesity-ovalbumin sensitization conditions in female rats.
نوع سند : | مقاله |
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زبان سند : | انگلیسی |
نویسنده اول : | رعنا کیهان منش |
نویسنده : | محمد رضا علیپور |
نویسنده : | هادی ابراهیمی |
نویسنده مسئول : | محمدرضا اصلانی |
ضریب تاثیر و نمایه مجلات: | IF:2.88 Indexed in: ISI, PubMed/Medline, Scopus |
کلیدواژه ها (انگلیسی): | airway hyperresponsiveness, asthma ,obesity, visfatin, female Wistar rats |
موضوعات : | QT فیزیولوژی WF سیستم تنفسی WK سیستم غدد |
بخش های دانشگاهی : | دانشكده پزشكي > گروه علوم پایه > بخش فیزیولوژی |
کد شناسایی : | 9733 |
ارائه شده توسط : | دکتر محمد رضا اصلانی |
ارائه شده در تاریخ : | 15 بهمن 1396 08:26 |
آخرین تغییر : | 26 شهریور 1402 13:08 |
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